Antibody ceiling effects following influenza vaccination

Slides: https://www.andreashandel.com/presentations/

Andreas Handel

2024-04-22

Acknowledgements

  • Zane Billings, Hayley Hemme - for doing most of the work
  • Ted Ross, Andrea Sant, Stacey Schultz-Cherry, Ben Cowling, Annette Fox - for data sharing
  • Many other colleagues and collaborators
  • NIH

Introduction

  • Increased pre-vaccination antibody titer results in reduced titer boost following vaccination (and infection)
  • Called response blunting, antibody ceiling effect, negative interference
  • For a nice summary, see Oidtman et al. 2021 Trends Mic

Linderman et al 2020

Questions

What is the shape of the ceiling effect?

Questions

How do other factors (e.g. age, sex, vaccine type/dose, antigenic distance) impact the ceiling effect?

Zarnitsyna et al 2015 Phil Trans B, 2016 Plos Path.

Questions

  • (When) should we care about the ceiling effect?

Questions

  • (When) should we care about the ceiling effect?

Questions

  • What mechanisms underlie the ceiling effect?