Analysis and Modeling to evaluate influenza vaccine responses

Slides: https://www.andreashandel.com/presentations/

Andreas Handel

2023-10-11

Financial disclosures

  • NIH support

Learning Objectives

  • Identify problems and possible solutions for comparing future universal influenza vaccine candidates.
  • Describe possible problems related to repeat influenza vaccinations.

Part 1 - Assessing influenza vaccine candidates

Current Influenza vaccines

  • Need to be reformulated almost every year because of virus evolution
  • Need to be taken annually, due to virus evolution and vaccine waning
  • Are not very good, even if the vaccine and circulating strains match

Future Influenza vaccines

  • Should protect for a long time (lifelong?)
  • Should have high efficacy
  • Should protect against a wide range of strains

Universal flu vaccine challenges

  • Many
    • How to assess/compare vaccine candidates

How do we define a vaccine response?

Quantifying vaccine responses

Quantifying vaccine responses