2021-02-22 13:09:50

Introduction

  • Inoculum dose is an important determinant of infection or vaccination outcomes.
  • For infection, higher dose is often associated with greater risk of infection (ID50) and more severe outcomes (LD50).
  • For vaccines, dose is thought to impact both immunogenicity and side effects (morbidity).

Impact of dose following infection: Some past and current work

Dose and virus load

Dose and virus load

Infectious bronchitis virus (IBV) infections of chickens. (Coronavirus!)

Dose and virus load

Dose and infected cells

Dose and virus load revisited

Dose does not always impact pathogen load